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Non-Alcoholic Steatohepatitis (NASH)

When Fatty Liver Progresses to Inflammation and Liver Damage

NASH is an advanced form of fatty liver disease where fat accumulation in the liver leads to inflammation and damage, even in people who do not consume alcohol. It can progress to cirrhosis and liver failure if untreated.
Quick Facts
🩺 Affects

Liver

⚠️ Cause

Fat accumulation + inflammation

📈 Progression

Fatty Liver → NASH → Cirrhosis

✅ Treatment

Reversible early; transplant later

Diagnosed with Fatty Liver or Metabolic Issues?

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What is NASH?

Non-Alcoholic Steatohepatitis (NASH) is a condition where fat buildup in the liver is accompanied by inflammation and liver cell injury.

Unlike simple fatty liver:

  • NASH causes active liver damage
  • Leads to scarring (fibrosis)
  • Can progress to cirrhosis

It is closely linked to lifestyle and metabolic disorders.

How NASH Affects the Liver
Fat Accumulation
Excess fat storage
Inflammation
Liver cell damage
Fibrosis
Scarring begins
Cirrhosis
Irreversible damage
Silent progression → Regular screening is important
Signs & Symptoms
Often Silent (Early Stage)

No obvious symptoms

When Symptoms Appear
  • Fatigue
  • Mild abdominal discomfort
  • Weakness
Causes & Risk Factors

Primary Causes:

  • Obesity
  • Type 2 diabetes
  • Insulin resistance

Risk Factors:

  • High cholesterol
  • Sedentary lifestyle
  • Poor diet
Disease Progression
Fatty Liver (NAFLD)
NASH
Fibrosis
Cirrhosis
End Stage Liver Disease

Check Your Liver Risk

Understand your metabolic liver risk

Diagnosis & Tests
✔️ Liver function tests (LFT)
✔️ Ultrasound
✔️ Fibroscan
✔️ MRI (selected cases)
✔️ Liver biopsy (definitive)
Treatment Options (Before Transplant)
1. Lifestyle Modification

Weight loss, Healthy diet, Exercise

2. Control Metabolic Conditions

Diabetes management, Lipid control

3. Medical Therapy

Selected medications

4. Monitoring

Regular liver evaluation

When is Liver Transplant Needed?
  • Cirrhosis develops
  • Liver function declines
  • Complications occur
NASH is Preventable and Reversible Early
Lifestyle changes can prevent liver failure
Liver Transplant Options

Living Donor Liver Transplant
Preferred in India

Cadaver Donor Transplant
Based on waiting list

Lifestyle/Medical vs Transplant
Early/ModerateAdvancedReverse inflammationReplace liverExcellent with complianceLife-saving
Factor Lifestyle/Medical Management Liver Transplant
Stage
Goal
Outcome
Important: Lifestyle is the Key Driver
Early stage is reversible. Weight loss significantly improves outcomes. Long-term lifestyle change is essential.
Get Personalized Guidance
Cost & Planning Guide
Find Specialist Near You
Patient Resources
Weight loss & diet guide
Diabetes management plan
Exercise routines
Donor evaluation and documentation
These involve structured clinical and legal protocols as per transplant guidelines.
FAQs

Yes, in early stages with lifestyle changes.

Yes, it is non-alcohol related.

Yes, if untreated.

Final Guidance

NASH is a lifestyle-related but preventable disease. Early action can completely avoid liver failure.